Fast, cheap biosensor for dengue virus

TEPIC, 9 June 2017:

Brazilian scientists have developed a biosensor that can quickly detect dengue and could help create a cheap tool to diagnose the painful mosquito-borne virus that infects millions each year.

They are looking to produce a testing kit that would cost clinics and hospitals around US$30 and take about 15 minutes to analyse blood samples for a key dengue protein, said Cleverton Luiz Pirich, a researcher at the Federal University of Paraná.

A biosensor is an analytical device that converts a biological response into an electrical signal.

“You can do a diagnosis very fast, at a very low cost, and you don’t need to have a lot of knowledge of this equipment,” Pirich said by telephone from Curitiba in southern Brazil.

“The innovation of our work is not specific to dengue – you can use it for other diseases.”

The scientists coated the biosensor with a thin film of bacterial cellulose nanocrystals, which effectively detected a protein known as NS1 from blood samples, according to results published in the journal Biosensors and Bioelectronics.

They now want to explore ways to create cost-effective biosensor components that could be used to analyse multiple blood samples, said Pirich.

The technology could potentially be adapted to detect proteins from viruses such as Zika, which is also transmitted by the Aedes aegypti mosquito, he added.

Endemic in Latin America and Asia, dengue infects hundreds of millions of people each year, and is becoming more prevalent. It is often hard to diagnose as the symptoms, which include fever and severe joint pain, are similar to a number of other diseases.

Simple tools such as testing blood from a finger prick, used to detect malaria, are not available for dengue, and there is no dedicated treatment for the virus which is usually found in urban and semi-urban areas.

Dengue has spread to more than 100 countries from nine in 1960, according to the World Health Organization, with cases rising to 390 million a year from 15,000 in 1960.

Experts say the increased movement of people and goods due to globalisation, as well as worsening floods linked to climate change, are likely to speed up the spread of dengue.

The economic impact is potentially huge, with the disease estimated to cost the Americas US$2.1 billion annually, while Southeast Asian economies could lose almost US$2.4 billion.

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